Chronic morphine induces tolerance and desensitization of μ-opioid receptor but not down-regulation in rabbit
- 15 January 1994
- journal article
- Published by Elsevier in European Journal of Pharmacology: Molecular Pharmacology
- Vol. 266 (2), 139-146
- https://doi.org/10.1016/0922-4106(94)90103-1
Abstract
No abstract availableKeywords
This publication has 30 references indexed in Scilit:
- Chronic exposure to morphine and naltrexone induces changes in catecholaminergic neurotransmission in rat brain without altering μ-opioid receptor sensitivityLife Sciences, 1993
- Phosphorylation of the recombinant spliced variants of the α-sub-unit of the stimulatory guanine-nucleotide binding regulatory protein (Gs) by the catalytic sub-unit of protein kinase aBiochemical and Biophysical Research Communications, 1992
- Reciprocal effects of chronic morphine administration on stimulatory and inhibitory G-protein α subunits in primary cultures of rat striatal neuronsEuropean Journal of Pharmacology: Molecular Pharmacology, 1991
- μ-Opioid receptor-regulated adenylate cyclase activity in primary cultures of rat striatal neurons upon chronic morphine exposureEuropean Journal of Pharmacology: Molecular Pharmacology, 1991
- Effect of chronic prenatal morphine treatment on μ-opioid receptor-regulated adenylate cyclase activity and neurotransmitter release in rat brain slicesEuropean Journal of Pharmacology: Molecular Pharmacology, 1991
- Apparent precoupling of κ- but not μ-opioid receptors with a G protein in the absence of agonistEuropean Journal of Pharmacology: Molecular Pharmacology, 1990
- Morphine-induced desensitization and down-regulation at mu-receptors in 7315c pituitary tumor cellsLife Sciences, 1989
- Repeated electroconvulsive shock or chronic morphine treatment increases the number of 3HDALA2, DLEU5enkephalin binding sites in rat brain membranesLife Sciences, 1982
- Influence of opiates on the levels of adenosine 3′ : 5′-cyclic monophosphate in neuroblastoma x glioma hybrid cellsLife Sciences, 1975
- Comparison of in vivo and in vitro parameters of opiate receptor binding in naive and tolerant/dependent rodentsLife Sciences, 1975