Laboratory characteristics of an attenuated influenza type A (H3N2) virus (‘Alice’ strain)
- 1 August 1976
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 77 (2), 181-188
- https://doi.org/10.1017/s0022172400024608
Abstract
Summary: The Alice strain of live attenuated influenza virus was obtained by selection of a γ inhibitor-resistant strain from a virus recombinant between A/PR/8/34 (H0N1) and A/England/42/72 (H3N2). Its behaviour in vitro and in vivo was studied. Three marker systems were investigated: resistance to serum inhibitors, growth capacity at high temperature and low sensitivity to amantadine hydrochloride. In ferrets the strain was found to be attenuated and immunogenic. Passages in man, animals and eggs have not affected its resistance to γ inhibitors.This publication has 18 references indexed in Scilit:
- Growth and pathogenicity of influenza viruses in organ cultures of ciliated epitheliumArchiv für die gesamte Virusforschung, 1974
- From the National Institutes of HealthThe Journal of Infectious Diseases, 1974
- Influenza Virus Plaque Formation in Different Species of Cell MonolayersJournal of General Virology, 1974
- Temperature-Sensitive Mutants of Influenza Virus. II. Attenuation of ts Recombinants for ManThe Journal of Infectious Diseases, 1972
- RECOMBINANT INFLUENZA-A VIRUSES AS LIVE VACCINES FOR MAN: Report to the Medical Research Council's Committee on Influenza and other Respiratory Virus VaccinesThe Lancet, 1971
- Laboratory characteristics of influenza a viruses attenuated for manArchiv für die gesamte Virusforschung, 1970
- Attenuation of human influenza a virusesBMJ, 1969
- STUDIES ON THE ANTIVIRAL ACTIVITY OF AMANTADINE HYDROCHLORIDE*Annals of the New York Academy of Sciences, 1965
- STUDIES OF TWO KINDS OF VIRUS PARTICLES WHICH COMPRISE INFLUENZA A2 VIRUS STRAINSThe Journal of Experimental Medicine, 1960
- Kaolin Treatment of Sera for Removal of Nonspecific Inhibitors to Asian Strains of Influenza Virus.Experimental Biology and Medicine, 1960