PROSTAGLANDIN MEDIATED NATRIURESIS DURING GLUCAGON INFUSION IN DOGS

Abstract

Ten .mu.g/min glucagon infused i.v. for 30 min in conscious dogs (wt 15-25 kg) increases renal prostaglandin [PG] activity and produces a natriuretic effect, which is impaired by indomethacin pretreatment. Cardiac output, heart rate, renal blood flow and urine c[cyclic]AMP excretion are similarly increased in non-pretreated and indomethacin pretreated dogs. Glucagon infusion does not consistently change plasma renin activity in non-pretreated dogs, while renin secretion is almost totally blocked when glucagon is administered to dogs pretreated with indomethacin. The results are consistent with the view that the natriuretic response to glucagon largely depends increased renal blood flow. An addition tubular PG mediated, and a possible anti-aldosterone effect is also involved.