CENTRAL EFFECTS PRODUCED BY INJECTION OF 48/80 INTO THE CEREBRAL VENTRICLES OF MICE
Open Access
- 1 June 1959
- journal article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 14 (2), 243-245
- https://doi.org/10.1111/j.1476-5381.1959.tb01392.x
Abstract
Injections of 20 to 30 μg. of 48/80 into the cerebral ventricular spaces of mice produced a condition of motor excitement termed “delirium ambulatorium.” This condition was aggravated by previous intraperitoneal injection of tranquillizers, atropine, and promethazine, not affected by previous injection of mepyramine and abolished by a previous injection of pentobarbitone. When an intraperitoneal injection of strychnine was followed by an intraventricular injection of 48/80, the strychnine convulsions became more violent, but the pattern of delirium ambulatorium was not produced.Keywords
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