After long, silent reflection I am still puzzled about the proper answer to Dr. Desjardins' thoughtful essay, for I quite agree with what he says. Dr. Desjardins writes that pathologists are contrary, earth-bound devils like the rest of the medical profession; this I know to be true from my own experience. Dr. Desjardins believes the histological method has limits beyond which it is dangerous to go; this I cannot deny because I too have written about the danger. Dr. Desjardins observes that pathologists habitually cultivate the confidence of surgeons; but what wise man does not? Dr. Desjardins writes that pathologists may form different opinions about the significance of a biopsy and even make misdiagnoses; but after all aren't we too physicians? Now, you see the causes of my puzzlement. How can I take issue with such a colleague? Indeed the foremost thought in my mind at the moment is that