Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease
- 12 December 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 43 (1), 43-47
- https://doi.org/10.1038/ng.733
Abstract
Michel Georges and colleagues perform high-throughput resequencing of 63 positional candidate genes identified through genome-wide association studies to search for rare coding variants influencing risk of Crohn's disease. They identify low-frequency coding variants in IL23R that confer protection against inflammatory bowel disease but conclude that rare coding variants in these positional candidates do not make a large contribution to Crohn's disease risk.Keywords
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