Positron emission tomography at the end of first-line therapy and during follow-up in patients with Hodgkin lymphoma: a retrospective study
- 9 November 2009
- journal article
- research article
- Published by Elsevier in Annals of Oncology
- Vol. 21 (6), 1222-1227
- https://doi.org/10.1093/annonc/mdp522
Abstract
Background: Routine positron emission tomography (PET) in follow-up of Hodgkin lymphoma (HL) after treatment is still controversial. The aim of this retrospective study was to analyze the clinical impact of routine PET examination during the follow-up for relapse detection in PET-negative HL patients at the end of therapy. Patients and methods: PET scans were carried out in 113 HL patients at the end of therapy and during the follow-up either in regular intervals or in a suspected relapse. Median follow-up of the group was 34 months. Results: Overall 327 PET scans were evaluated in 113 patients (median three PET scans per patient). At the end of therapy, 94 (83.2%) patients were PET negative and 19 (16.8%) PET positive. Regular follow-up PET scans in 67 of 94 PET-negative patients correctly identified tumor in 6 of 155 PET scans (3.9%). In 27 of 94 patients with clinically suspected relapse, 5 of 27 PET scans (18.5%) confirmed tumor. Conclusions: Our analysis showed that there is no need for regular follow-up with PET scans in PET-negative patients at the end of therapy: the ratio of true-positive PET scans during the follow-up is low (3.9%). Positive PET at the end of therapy and during follow-up should be evaluated with caution.Keywords
Funding Information
- Ministry of Public Health, Czech Republic (MSM0021620808)
This publication has 24 references indexed in Scilit:
- 18F-FDG PET for Posttherapy Assessment of Hodgkin's Disease and Aggressive Non-Hodgkin's Lymphoma: A Systematic ReviewJournal of Nuclear Medicine, 2007
- Impact of Positive Positron Emission Tomography on Prediction of Freedom From Progression After Stanford V Chemotherapy in Hodgkin's DiseaseJournal of Clinical Oncology, 2007
- Revised Response Criteria for Malignant LymphomaJournal of Clinical Oncology, 2007
- PET and PET/CT for response evaluation in lymphoma: Current practice and developmentsLeukemia & Lymphoma, 2007
- Hodgkin lymphoma: Response assessment by Revised International Workshop CriteriaLeukemia & Lymphoma, 2007
- Follow-up of patients with Hodgkin's disease following curative treatment: the routine CT scan is of little valueBritish Journal of Cancer, 2003
- Thoracic positron emission tomography using18F-fluorodeoxyglucose for the evaluation of residual mediastinal Hodgkin diseaseBlood, 2001
- Report of an International Workshop to Standardize Response Criteria for Non-Hodgkin's LymphomasJournal of Clinical Oncology, 1999
- Detection of relapse in early-stage Hodgkin's disease: role of routine follow-up studies.Journal of Clinical Oncology, 1997
- Follow up policy after treatment for Hodgkin's disease: too many clinic visits and routine tests? A review of hospital recordsBMJ, 1997