Antifungal agents. 5. Chemical modification of antibiotics from Polyangium cellulosum var fulvum. Alcohol, ketone, aldehyde and oxime analogs of ambruticin

Abstract

Alcohol, ketone, aldehyde and oxime analogs of ambruticin were prepared. The analogs were tested against Histoplasma capsulatum, Microsporum fulvum, Candida albicans and Streptococcus pyogenes. Structure-activity relationships are desribed. Increasing the bulk of substituent at C1 and C5 reduces antifungal activity.