Size-dependent antimicrobial properties of sugar-encapsulated gold nanoparticles synthesized by a green method
Open Access
- 12 November 2012
- journal article
- research article
- Published by Springer Nature in Nanoscale Research Letters
- Vol. 7 (1), 623
- https://doi.org/10.1186/1556-276x-7-623
Abstract
The antimicrobial properties of dextrose-encapsulated gold nanoparticles (dGNPs) with average diameters of 25, 60, and 120 nm (± 5) and synthesized by green chemistry principles were investigated against both Gram-negative and Gram-positive bacteria. Studies were performed involving the effect of dGNPs on the growth, morphology, and ultrastructural properties of bacteria. dGNPs were found to have significant dose-dependent antibacterial activity which was also proportional to their size. Experiments revealed the dGNPs to be bacteriostatic as well as bactericidal. The dGNPs exhibited their bactericidal action by disrupting the bacterial cell membrane which leads to the leakage of cytoplasmic content. The overall outcome of this study suggests that green-synthesized dGNPs hold promise as a potent antibacterial agent against a wide range of disease-causing bacteria by preventing and controlling possible infections or diseases.Keywords
This publication has 48 references indexed in Scilit:
- Single-Step Biofriendly Synthesis of Surface Modifiable, Near-Spherical Gold Nanoparticles for Applications in Biological Detection and CatalysisLangmuir, 2011
- Gold Nanoparticle–Fluorophore Complexes: Sensitive and Discerning “Noses” for Biosystems SensingAngewandte Chemie International Edition, 2010
- The Effects of Size, Shape, and Surface Functional Group of Gold Nanostructures on Their Adsorption and Internalization by CellsSmall, 2010
- Copper nanoparticles exert size and concentration dependent toxicity on somatosensory neurons of ratNanotoxicology, 2009
- On the Enhanced Antibacterial Activity of Antibiotics Mixed with Gold NanoparticlesNanoscale Research Letters, 2009
- DNA damage response to different surface chemistry of silver nanoparticles in mammalian cellsToxicology and Applied Pharmacology, 2008
- Inhibition of HIV Fusion with Multivalent Gold NanoparticlesJournal of the American Chemical Society, 2008
- Antibacterial Activity and Mechanism of Action of the Silver Ion in Staphylococcus aureus and Escherichia coliApplied and Environmental Microbiology, 2008
- Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systemsApplied Physics Letters, 2007
- Does the Antibacterial Activity of Silver Nanoparticles Depend on the Shape of the Nanoparticle? A Study of the Gram-Negative Bacterium Escherichia coliApplied and Environmental Microbiology, 2007