Resistance of human tumors to cancer chemotherapeutic agents: An important research problem
- 1 January 1978
- journal article
- review article
- Published by Wiley in Medical and Pediatric Oncology
- Vol. 5 (1), 105-114
- https://doi.org/10.1002/mpo.2950050117
Abstract
The mechanisms whereby malignant cells become biochemically resistant to anti-cancer drugs are surveyed, with emphasis on human tumors. Methotrexate is used as a model to illustrate the mechanisms of resistance that can occur, and how cells can increase their production of dihyrofolate reductase, the target enzyme. Drug resistance remains one of the major impediments to the successful use of chemotherapy for neoplastic diseases.Keywords
This publication has 25 references indexed in Scilit:
- Transport of Methotrexate into Normal Haemopoietic Cells and into Leukaemic Cells and its Effects on DNA SynthesisBritish Journal of Haematology, 1973
- Active outward transport of daunomycin in resistant ehrlich ascites tumor cellsBiochimica et Biophysica Acta (BBA) - Biomembranes, 1973
- THE CHARACTERISTICS OF THE MEMBRANE TRANSPORT OF AMETHOPTERIN AND THE NATURALLY OCCURRING FOLATESAnnals of the New York Academy of Sciences, 1971
- Alterations in enzyme activity in tumors and the implications for chemotherapyAdvances in Enzyme Regulation, 1970
- On the role of drug penetration in amethopterin resistance of Sarcoma-180 cells in vitroBiochimica et Biophysica Acta (BBA) - Biophysics including Photosynthesis, 1965
- Studies concerning the inhibition of cellular reproduction by deoxyribonucleosides: I. Inhibition of the synthesis of deoxycytidine by a phosphorylated derivative of thymidineBiochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects, 1963
- A biochemical basis for resistance of L1210 mouse leukemia to 6-thioguanineBiochemical Pharmacology, 1963
- Defective transport of amethopterin (methotrexate) as a mechanism of resistance to the antimetabolite in L5178Y leukemic cellsBiochemical Pharmacology, 1962
- Metabolism of uracil and 5-fluorouracil by drug-sensitive and by drug-resistant bacteriaBiochimica et Biophysica Acta, 1960
- Possible Enzymic Mechanism for the Development of Resistance against Fluorouracil in Ascites TumoursNature, 1959