Biochemical Changes Associated with Toxic Exposures to Polytetrafluoroethylene Pyrolysis Products
- 1 January 1968
- journal article
- research article
- Published by Taylor & Francis in Aihaj Journal
- Vol. 29 (1), 49-53
- https://doi.org/10.1080/00028896809342980
Abstract
Rats were exposed to the products of pyrolysis of polytetrafluoroethylene (PTFE) containing hydrolyzable fluoride equivalent to 50 ppm COF2 for one hour daily. After one exposure, urinary excretion of fluoride was four times normal. Weight loss of exposed animals indicated inhibition of metabolism. Changes in succinic dehydrogenase activity in vivo correlated with exposure to pyrolysis products of PTFE and with urinary fluoride concentrations. Toxic effects of daily sublethal exposures were found to be cumulative. The metabolic inhibition observed was reversible. The toxic syndrome of daily inhalation of pyrolysis products of PTFE is compatible with descriptions of fluoride poisoning.This publication has 4 references indexed in Scilit:
- The Toxicity of Polytetrafluoroethylene Pyrolysis Products—Including Carbonyl Fluoride and a Reaction Product, Silicon TetrafluorideAihaj Journal, 1968
- The Identification of Toxic Compounds in the Pyrolysis Products of Polytetrafluoroethylene (PTFE)Aihaj Journal, 1968
- Comparison of the Reduction of Two Tetrazolium Salts with Succinoxidase Activity of Tissue HomogenatesJNCI Journal of the National Cancer Institute, 1957
- The effect of fluoride on succinic oxidase systemBiochemical Journal, 1952