Increased plasma binding of quinidine after surgery: A preliminary report
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 10 (6), 441-444
- https://doi.org/10.1007/bf00563081
Abstract
The plasma binding of quinidine and phenytoin has been studied pre- and postoperatively in nine patients submitted to planned gastric surgery. The binding of phenytoin showed a slight and transient reduction, whilst quinidine binding was markedly increased, on average from 78.5 % on the day of operation to a maximum of 87.5 %, after 2 – 4 days. The time course of the increase was strikingly parallel to that of the concentration of certain acute phase proteins.This publication has 12 references indexed in Scilit:
- Spuriously low plasma propranolol concentrations resulting from blood collection methodsClinical Pharmacology & Therapeutics, 1975
- Increased binding of quinidine to serum albumin and lipoproteins in anuric ratsEuropean Journal of Pharmacology, 1975
- The binding of quinidine to protein fractions of normal human seraBiochemical Pharmacology, 1975
- Pharmacokinetic Drug InteractionsPublished by Springer Nature ,1975
- Diphenylhydantoin Binding to Proteins in Plasma and Its Dependence on Free Fatty Acid and Bilirubin Concentration in Dogs and Newborn InfantsPediatric Research, 1975
- Plasma protein binding of diphenylhydantoin Effects of sex hormones, renal and hepatic diseaseClinical Pharmacology & Therapeutics, 1974
- Effect of in vivo Elevation of Free Fatty Acids on Protein Binding of DrugsPharmacology, 1974
- Protein Binding of Diphenylhydantoin and Desmethylimipramine in Plasma from Patients with Poor Renal FunctionNew England Journal of Medicine, 1971
- Plasma protein binding of diphenylhydantoin in normal and hyperbilirubinemic infantsThe Journal of Pediatrics, 1971
- ABNORMAL PHARMACOKINETICS OF PHENYTOIN IN A PATIENT WITH URÆMIAThe Lancet, 1970