The use of radioimmunoassay to study the formation and disappearence of O6-methylguanine in mouse liver satellite and main-band DNA following dimethylnitrosamine administration
- 1 November 1980
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 98 (2), 127-138
- https://doi.org/10.1007/bf00405957
Abstract
A sensitive radioimmunoassay for O6-methyldeoxyguanosine has been developed, permitting the analysis of microgram amounts of DNA. This technique has been used in the study of the formation and removal of O6-methylguanine in mouse liver satellite and main-band DNA. The results indicate a reduced extent of O6-methylguanine formation in satellite DNA but similar rates of its removal from both classes of DNA.Keywords
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