HLA, AND THE RESPONSE TO TREATMENT WITH γ‐TYPE ENDORPHINS IN SCHIZOPHRENIA
- 1 December 1982
- journal article
- Published by Wiley in International Journal of Immunogenetics
- Vol. 9 (6), 381-388
- https://doi.org/10.1111/j.1744-313x.1982.tb00999.x
Abstract
In order to investigate whether genetic factors are involved in the response of schizophrenic patients to treatment with γ-type endorphins, we typed 32 Dutch schizophrenic patients for the HLA-A, -B, -C and -DR antigens. The total patient group showed an increase of HLA-Bw4 and HLA-Cw1. A subgroup of 20 paranoid patients showed an increase of HLA-Cw1 and a significant heterogeneity for the HLA-C locus. In 16 patients who responded moderately or markedly to treatment with γ-type endorphins, an increase of HLA-B15/Cw3 and a decrease of HLA-B17 were found as compared to 16 patients with no or a slight response. Moreover, HLA-B15 was particularly increased in those patients who responded markedly and remained free of psychotic symptoms for a period of at least 6 months after treatment with γ-type endorphins (RR = 24.6, Puncorr.= 0.0015).Our results suggest that genetic factors coded for within the HLA region are associated with paranoid schizophrenia, and that HLA-B15/Cw3 is associated with a marked and prolonged response to treatment with γ-type endorphins.Keywords
This publication has 21 references indexed in Scilit:
- Interaction of Penicillin with HLA-A and -B antigensHuman Immunology, 1982
- Depressive Disorders and HLA: A Gene on Chromosome 6 That Can Affect BehaviorNew England Journal of Medicine, 1981
- Intermittent versus continuous stimulation: Effect of time interval on the development of sensitization or toleranceLife Sciences, 1980
- HLA Antigens in Schizophrenia: Differences between Patients with and without Evidence of Brain AtrophyThe British Journal of Psychiatry, 1980
- HLA ANTIGENS AS POSSIBLE MARKERS OF HETEROGENEITY IN SCHIZOPHRENIAInternational Journal of Immunogenetics, 1978
- Interference between anti‐HLA Antibodies and Adrenergic Receptor‐Binding DrugsTissue Antigens, 1977
- The Hla System and the Clinical Response to Treatment with ChlorpromazineThe British Journal of Psychiatry, 1976
- INTERACTION OF HLA MOLECULES WITH NON-IMMUNOLOGICAL LIGANDS AS AN EXPLANATION OF HLA AND DISEASE ASSOCIATIONSThe Lancet, 1976
- C fragment of lipotropin has a high affinity for brain opiate receptorsNature, 1976
- Identification of two related pentapeptides from the brain with potent opiate agonist activityNature, 1975