Dilantin Sensitivity

Abstract

THE use of Dilantin Sodium (sodium diphenyl hydantoinate) has become widespread since the introductory study by Merritt and Putnam,¹ who described certain toxic effects in the course of its administration. These are chiefly referable to the central nervous system, gastrointestinal tract, skin, gums and hematopoietic system. They observed cutaneous lesions in 5 per cent of their cases. These varied from mild erythema to a diffuse morbilliform eruption and, in 1 case, severe generalized exfoliative dermatitis. The incidence of the toxic effects of Dilantin have varied from 58 per cent ² to 93 per cent ³ in a number of subsequent reports.^{2 3 4 5 6 7 8 9 10 11 12} Fortunately, . . .