Folic Acid for the Prevention of Colorectal Adenomas
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Open Access
- 6 June 2007
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 297 (21), 2351-2359
- https://doi.org/10.1001/jama.297.21.2351
Abstract
Folic acid and its derivatives (folate) are essential nutrients in humans and play an important role in nucleotide synthesis and methylation reactions.1 Folate deficiency leads to macrocytic anemia, and abundant evidence indicates that even in well-nourished western populations, folate supplementation reduces the risk of neural tube defects.2Keywords
This publication has 34 references indexed in Scilit:
- Serrated polyps of the large intestineSeminars in Diagnostic Pathology, 2005
- Folate, colorectal carcinogenesis, and DNA methylation: Lessons from animal studiesEnvironmental and Molecular Mutagenesis, 2004
- A Randomized Trial of Aspirin to Prevent Colorectal AdenomasNew England Journal of Medicine, 2003
- Epidemiologic Studies of Folate and Colorectal Neoplasia: a ReviewJournal of Nutrition, 2002
- Relationship of Folate, Vitamin B-6, Vitamin B-12, and Methionine Intake to Incidence of Colorectal CancersNutrition and Cancer, 2002
- Fortification of Foods with Folic Acid — How Much is Enough?New England Journal of Medicine, 2000
- Multivitamin Use, Folate, and Colon Cancer in Women in the Nurses' Health StudyAnnals of Internal Medicine, 1998
- PERICONCEPTIONAL VITAMIN USE, DIETARY FOLATE, AND THE OCCURRENCE OF NEURAL TUBE DEFECTSEpidemiology, 1995
- Alcohol, Low-Methionine-Low-Folate Diets, and Risk of Colon Cancer in MenJNCI Journal of the National Cancer Institute, 1995
- Epidemiology of Colorectal AdenomasEpidemiologic Reviews, 1994