Synthesis of 3-trifluoromethylfurans from β,β-bis(trifluoromethyl)α,β-unsaturated ketones and tin(II) chloride

Abstract
A new building block strategy for the synthesis of 3-trifluoromethyl-substituted furans 9 and 10 is described from β,β-bis(trifluoromethyl)α,β-unsaturated ketones 2via reductive fluoride elimination and 1,5-electrocyclization with elimination.