Isolation and Properties of a Thymidylate-less Mutant in Saccharomyces cerevisiae
- 1 August 1975
- journal article
- Published by Wiley in European Journal of Biochemistry
- Vol. 56 (2), 533-538
- https://doi.org/10.1111/j.1432-1033.1975.tb02259.x
Abstract
A mutant, tmp3, has been isolated in Saccharomyces cerevisiae. Genetic and physiological analysis show that a single mendelian gene controls the multiple requirements for thymidylate, methionine, adenine and histidine and a neutral cytoplasmic petite character. Crude extracts of this mutant present a 60% decrease of serine transhydroxymethylase specific activity as compared to a wild-type strain.Keywords
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