Catalytic asymmetric hydrogenation of aldehydes
- 5 April 2007
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 17,p. 1739-1741
- https://doi.org/10.1039/b703977h
Abstract
Racemic α-arylaldehydes provide the corresponding primary alcoholsvia dynamic kinetic resolution in excellent enantioselectivities and yields upon hydrogenation using a Noyori ruthenium catalyst; for example, the biologically active (S)-enantiomer of the non-steroidal anti-inflammatory drug ibuprofen could be synthesized via catalytic enantioselective hydrogenation of aldehyde1f followed by oxidation with potassium permanganate in 76% isolated yield and 96 : 4 er.Keywords
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