Gluten and the Gut--Lessons for Immune Regulation
- 27 September 2002
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 297 (5590), 2218-2220
- https://doi.org/10.1126/science.1077572
Abstract
Celiac sprue is a common disease in which an immune response to the gluten in wheat results in an inflammatory reaction in the small intestine that can prevent the absorption of nutrients. In a Perspective, Schuppan and Hahn discuss new work (Shanet al.) that identifies a 33-amino acid peptide in gluten that contains the major immunogenic epitopes. This discovery opens the door to developing therapeutic strategies to treat celiac sprue by destroying this peptide.Keywords
This publication has 13 references indexed in Scilit:
- Structural Basis for Gluten Intolerance in Celiac SprueScience, 2002
- The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptidesGastroenterology, 2002
- Specificity of Tissue Transglutaminase Explains Cereal Toxicity in Celiac DiseaseThe Journal of Experimental Medicine, 2002
- An overview of regulatory T cellsMicrobes and Infection, 2001
- Type 1 T regulatory cellsImmunological Reviews, 2001
- Current concepts of celiac disease pathogenesisGastroenterology, 2000
- Molecular Basis of Celiac DiseaseAnnual Review of Immunology, 2000
- Diagnosis of celiac sprueGastroenterology, 1998
- Gliadin-specific, HLA-DQ(alpha 1*0501,beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients.The Journal of Experimental Medicine, 1993
- Possible Involvement of Transglutaminase in Endocytosis and Antigen PresentationMicrobiology and Immunology, 1985