The Effects of Cyclooxygenase-2 Inhibitors and Nonsteroidal Anti-inflammatory Therapy on 24-Hour Blood Pressure in Patients With Hypertension, Osteoarthritis, and Type 2 Diabetes Mellitus

Abstract
Elevated systolic blood pressure (SBP) places patients with type 2 diabetes at risk for premature renal and cardiovascular disease.1-3 With aging, patients with diabetes and hypertension often have coexisting osteoarthritis, which is most frequently managed with nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 (COX-2) inhibitors.4