EFFECT OF POLYMYXIN ON THE LYSIS OF NEISSERIA CATARRHALIS BY LYSOZYME
- 1 December 1957
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 74 (6), 788-793
- https://doi.org/10.1128/jb.74.6.788-793.1957
Abstract
Lysis of N. catarrhalts, as well as other gram-negative bacteria by lysozyme was demonstrated in cells pretreated with polymyxin B sulfate. Polymyxin action is not enzymatic; antibiotic-cell action takes place immediately at the temperature range studied. Electron micrographs of polymyxin-treated cells of N. catarrhalis show no alteration in the surface structure of the cells. This observation together with the marked damage of the cells following lysozyme treatment reflects a disorganization of the cell wall which renders the mucopolysaccharide substrate accessible to the action of lysozyme.Keywords
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