Evaluation of the thermodynamic parameters for the interconversion of the conformational isomers of two N-acyl-prolines by nuclear magnetic resonance spectroscopy

Abstract

Study of the ¹H n.m.r. spectra of the N-acyl-prolines (I) and (II) in deuteriochloroform over a range of temperature has enabled the thermodynamic parameters for the interconversion of such conformers by rotation about the N–CO bond to be evaluated for the first time.