The Identification of Four Metabolic Products after Incubation of p -Methoxyamphetamine with Liver Preparations of Various Species

Abstract

1. The metabolism in vitro of p-methoxyamphetamine by liver preparations of rabbit, guinea-pig and rat was investigated. 2. Four metabolic products, N-hydroxy-p-methoxyamphetamine, 1-(p-methoxyphenyl)-propan-2-one oxime, 1-(p-methoxyphenyl)-propan-2-one and 1-(p-methoxyphenyl)-propan-2-ol were isolated and identified by comparing physical properties with those of authentic compounds. 3. The properties and assay procedures for the examination of the labile N-hydroxy-p-methoxyamphetamine were investigated.