Effects of Fat and Carbohydrate Ingestion in Human Beings on Serum Lipids and Intracellular Lipid Deposition in Tissue Culture

Abstract

OUR investigation of the etiology of human atherosclerosis is based on the hypothesis that lipids in the serum are in equilibrium with the cells in the adjacent arterial tissue, that deposition in the latter is dependent upon the amount, quality and state of circulating lipid, and the metabolic state of and the degree to which lipid serves as a source of energy for the cells and that human atherosclerosis is an expression of a disturbance in the equilibrium such that lipids are deposited or synthesized and retained by arterial tissue with the production of permanent lesions in the form of . . .