High molecular weight opioid-containing proteins in striatum.
- 1 August 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 75 (8), 4021-4023
- https://doi.org/10.1073/pnas.75.8.4021
Abstract
Striatal extracts of guinea pigs, rats, and cattle contained 2 large proteins (> 40,000 and > 100,000 daltons) that on treatment with trypsin yield opioid peptides differing chromatographically from the opioid nonapeptide generated by trypsin digestion of endorphins, .beta.-lipotropin or pro-opiocortin. The large opioid proteins found in the pituitary do not appear to be present in the striatum. The striatal enkephalins may be produced via a pathway that differs from the 1 deduced from studies on the pituitary.This publication has 11 references indexed in Scilit:
- Coordinate synthesis of corticotropins and endorphins by mouse pituitary tumor cells.Journal of Biological Chemistry, 1978
- Characterization of pro-opiocortin, a precursor to opioid peptides and corticotropin.Proceedings of the National Academy of Sciences of the United States of America, 1978
- Isolation and characterization of the opioid peptides from rat pituitary: beta-endorphin.Proceedings of the National Academy of Sciences, 1977
- A morphine-like factor in mammalian brain: Analgesic activity in ratsBrain Research, 1977
- Isolation and characterization of the opioid peptides from rat pituitary: beta-lipotropin.Proceedings of the National Academy of Sciences, 1977
- Common precursor to corticotropins and endorphinsProceedings of the National Academy of Sciences, 1977
- Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor.Proceedings of the National Academy of Sciences, 1976
- beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins.Proceedings of the National Academy of Sciences of the United States of America, 1976
- Identification of two related pentapeptides from the brain with potent opiate agonist activityNature, 1975
- Minimal O2Consumption as an Index of Thyroid Status: Standardization of MethodEndocrinology, 1973