Neuraminic Acid as a Constituent of Human Cerebrospinal Fluid.
- 1 December 1956
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 93 (3), 497-501
- https://doi.org/10.3181/00379727-93-22796
Abstract
The neuraminic acid (NA) content of 49 samples of human cerebrospinal fluid (CSF) was studied. In all instances the quantitative relationship of neuraminic acid to the cerebrospinal fluid protein was far in excess of that prevalent in serum. In 26 samples in which the total protein was 30 mg % or less, the neuraminic acid was 4-18 times in excess of that expected if it were derived from serum and bound to protein, as is the case in blood. Unlike its state in serum, most of the CSF neuraminic acid is in freely dialyzable form (60-80%). That moiety of CSF neuraminic acid which is derived from serum is in protein-bound, nondialyzable form. The origin of the dialyzable NA is unknown, but is not related to ingress of serum proteins into the CSF. The implications of these findings are discussed.Keywords
This publication has 5 references indexed in Scilit:
- Isolation and Determination of the Glycoproteins in Cerebrospinal Fluid.Experimental Biology and Medicine, 1955
- Gynaminic acid. A naturally occurring form of neuraminic acid in human milkArchives of Biochemistry and Biophysics, 1955
- Über die enzymatische Wirkung von InfluenzavirusHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1955
- STUDIES ON THE MUCOPROTEINS OF HUMAN PLASMA .5. ISOLATION AND CHARACTERIZATION OF A HOMOGENEOUS MUCOPROTEIN1950
- AN ELECTROPHORETIC STUDY OF THE PROTEIN COMPONENTS IN CEREBROSPINAL FLUID AND THEIR RELATIONSHIP TO THE SERUM PROTEINS 1JCI Insight, 1942