Rga (Rodgers) and the HLA Region: Linkage and Associations
- 31 July 1976
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 8 (2), 143-149
- https://doi.org/10.1111/j.1399-0039.1976.tb00564.x
Abstract
In 19 families with 97 children, the segregation of Rga (Rodgers) was compatible with Mendelian inheritance, and 5 backcross and 14 intercross families were found among HLA [human histocompatability antigen] and Bf typed families. Close linkage (lods + 17.82) without recombination was found between Rg and the HLA region, with a direct count of 96 nonrecombinant meioses for Rg-HLA-B. Rg- was strongly associated with HLA-B8 (29 of 30 haplotypes) and probably associated with Bw40, but did occur on other HLA-B haplotypes. By inference Rg- is negatively associated with Ch- (Chido). The Rg-Ch- haplotype was not observed. Rga and Cha may or may not be coded for different sites of the same cistron closely linked to HLA-B:C and cannot as yet be excluded from being parts of B or C.This publication has 10 references indexed in Scilit:
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