A gene apparently determining the extent of sialylation of lysosomal ?-mannosidase in mouse liver
- 1 February 1977
- journal article
- research article
- Published by Springer Nature in Biochemical Genetics
- Vol. 15 (1-2), 31-46
- https://doi.org/10.1007/bf00484546
Abstract
Organ-specific electrophoretic heterogeneity of lysosomal α-mannosidase has been observed within individual strains of inbred mice. Polymorphism between C57BL/6J and CBA/J for liver lysosomal α-mannosidase is determined by a single genetic locus on chromosome 5 and appears to be the result of differences in sialylation of the lysosomal enzyme. Two different patterns of expression of development of the liver electrophoretic forms have been observed.Keywords
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