Hemodynamic Influence of Sodium Iothalamate on Controlled Pulmonary Circulation

Abstract

The effect of injection of Angio-Conray (sodium iothalamate) into the pulmonar) artery was tested in nine animals in whom pulmonary blood flow, left atrial pressure and heart rate were maintained as constant. This preparation isolates the effects of systemic and left heart hemodynamics. The results indicate that administration of Angio-Conray to animals without known anatomic abnormality of the pulmonary circulation failed to produce alteration in pulmonary hemodynamics. These studies suggest that observed alterations in other preparations, and perhaps in patients, are secondary to alterations in systemic hemodynamics or the response of an abnormal pulmonary circulation “ to the test agent.