Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia
Open Access
- 15 September 1999
- journal article
- Published by American Society of Hematology in Blood
- Vol. 94 (6), 1840-1847
- https://doi.org/10.1182/blood.v94.6.1840.418k06_1840_1847
Abstract
Cellular immunophenotypic studies were performed on a cohort of randomly selected IgM+ B-chronic lymphocytic leukemia (B-CLL) cases for which Ig VH and VL gene sequences were available. The cases were categorized based on V gene mutation status and CD38 expression and analyzed for treatment history and survival. The B-CLL cases could be divided into 2 groups. Those patients with unmutated V genes displayed higher percentages of CD38+ B-CLL cells (≥30%) than those with mutated V genes that had lower percentages of CD38+ cells (Keywords
This publication has 37 references indexed in Scilit:
- The Normal Counterpart of IgD Myeloma Cells in Germinal Center Displays Extensively Mutated IgVH Gene, Cμ–Cδ Switch, and λ Light Chain ExpressionThe Journal of Experimental Medicine, 1998
- Cancer statistics, 1998CA: A Cancer Journal for Clinicians, 1998
- Role of the human CD38 molecule in B cell activation and proliferationTissue Antigens, 1997
- Examples of in vivo isotype class switching in IgM+ chronic lymphocytic leukemia B cells.Journal of Clinical Investigation, 1996
- A unique spectrum of p53 mutations in B‐cell chronic lymphocytic leukemia distinct from that of other lymphoid malignanciesMolecular Carcinogenesis, 1995
- Analysis of somatic mutation in five B cell subsets of human tonsil.The Journal of Experimental Medicine, 1994
- The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoireImmunology Today, 1994
- CD38 signaling by agonistic monoclonal antibody prevents apoptosis of human germinal center B cellsEuropean Journal of Immunology, 1994
- Regulation of Human B-Cell Activation and AdhesionAnnual Review of Immunology, 1991
- Prognostic factors in chronic lymphocytic leukaemia: the importance of age, sex and response to treatment in survivalBritish Journal of Haematology, 1989