Increased frequency of HLA-A3 in subjects with sporadic porphyria cutanea tarda
- 1 May 1988
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 31 (5), 250-251
- https://doi.org/10.1111/j.1399-0039.1988.tb02091.x
Abstract
The HLA-A3 alloantigen, usually associated with the hemochromatosis gene, was detected in 12 of 18 patients (67%) with sporadic porphyria cutanea tarda but in only 23 per cent of 328 normal subjects (p = 0.0006). This difference remained significant after correcting for the number of HLA-A locus antigens tested (p = 0.025). These results suggest that an HLA-linked hemochromatosis allele is present and may account for the iron abnormalities in many patients with sporadic porphyria cutanea tarda.This publication has 13 references indexed in Scilit:
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