A Molecular Marker for Chloroquine-Resistant Falciparum Malaria
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Open Access
- 25 January 2001
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 344 (4), 257-263
- https://doi.org/10.1056/nejm200101253440403
Abstract
Chloroquine-resistant Plasmodium falciparum malaria is a major health problem, particularly in sub-Saharan Africa. Chloroquine resistance has been associated in vitro with point mutations in two genes, pfcrt and pfmdr 1, which encode the P. falciparum digestive-vacuole transmembrane proteins PfCRT and Pgh1, respectively.Keywords
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