Untersuchungen über das Zustandekommen der bösartigen Geschwülste. 4. Über den Gehalt von normalen und Krebsgeweben an Milchsäure, Cytochrom und Glutathion.

Abstract

In tissues formed of epithelium and connective tissue the amount of cytochrome present was proportional to the presence of epithelial cells. This was also true for cancerous tissues, and the same relationship held for the presence of lactic acid and glutathion. The writers further emphasize their view that the high lactic acid content of tumor tissue was the result of inhibited resynthesis, and believe that it may be at least in part a post-removal phenomenon. As regards constancy of the SH value in glutathion determinations, further work showed that this increased appreciably after removal of the tissue from the living animal. Concerning cytochrome, in view of the readiness with which its oxidized form was reduced under conditions of elevated temp., they believe that this may be present in the living tissue in the oxidized form, reduction taking place rapidly after removal and interruption of the normal access of O2.