ACTIVE IMMUNITY TO POLIOMYELITIS IN CHIMPANZEES FOLLOWING SUBCLINICAL INFECTION
Open Access
- 1 March 1947
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 85 (3), 287-303
- https://doi.org/10.1084/jem.85.3.287
Abstract
This report is concerned with the production of subclinical poliomyelitis in the chimpanzee, and immunity to such infection. Subclinical infection was produced in eight chimpanzees by the administration of virus orally or intracutaneously, and was measured by the production of a virus carrier state and the development of neutralizing antibodies. Immunity was tested by attempting to induce the carrier state again by a challenge dose of virus by the same routes. With an homologous strain as the challenge virus, immunity as defined here was produced in each of four chimpanzees tested. Neutralizing antibodies to the homologous strain were present about 1 month following the first exposure to virus by either the oral or cutaneous route. In another group of two chimpanzees, one developed neutralizing antibodies and immunity to heterologous strains, and one did not.Keywords
This publication has 8 references indexed in Scilit:
- Sedimentation of Poliomyelitis Virus in the Sharples CentrifugeThe Journal of Immunology, 1946
- Poliomyelitis Virus in Fly-Contaminated Food Collected at an EpidemicScience, 1945
- NON-PARALYTIC POLIOMYELITIS IN THE CHIMPANZEEThe Journal of Experimental Medicine, 1945
- PASSIVE IMMUNITY TO POLIOMYELITIS IN THE CHIMPANZEEThe Journal of Experimental Medicine, 1945
- THE ULTRACENTRIFUGE AS AN AID IN THE DETECTION OF POLIOMYELITIS VIRUSThe Journal of Experimental Medicine, 1943
- INTRACUTANEOUS INOCULATION OF POLIOMYELITIS VIRUS IN MONKEYS AND ITS DETECTION IN THEIR STOOLSAnnals of Internal Medicine, 1942
- STUDIES OF A MURINE STRAIN OF POLIOMYELITIS VIRUS IN COTTON RATS AND WHITE MICEThe Journal of Experimental Medicine, 1940
- The Experimental Transmission of Poliomyelitis to the Eastern Cotton Rat, Sigmodon hispidus hispidusPublic Health Reports®, 1939