Turnover of rat liver ornithine transcarbamylase
- 2 November 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 208 (2), 427-430
- https://doi.org/10.1016/0014-5793(86)81062-6
Abstract
The relative half-life of ornithine transcarbamylase from rat liver has been determined using the double isotope technique and affinity chromatography. The calculated half-life (6-9 days) is similar to that of mitochondria and of the other mitochondrial enzyme of the urea cycle, carbamoyl-phosphate synthase. Therefore, both mitochondrial urea cycle enzymes are most probably degraded mainly via the lysosomal (autophagic) pathway of mitochondrial protein degradation.Keywords
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