INVESTIGATIONS ON COMBINED INJURIES .29. PROTECTIVE EFFECT OF "AMINOPROPYLAMINO-ETHYLTHIOPHOSPHATE (WR-2721) IN MICE WITH RADIATION AND COMBINED INJURIES (IRRADIATION AND SKIN WOUND OR BURN)

Abstract

The efficacy of the radioprotective agent aminopropylaminoethylthiophosphate (WR 2721) on mice which were whole-body X-irradiated and stressed with a 2nd trauma, an open wound or burn wounds on the skin was studied. In whole-body irradiation, probit analyses yielded the dose reduction factors (DRF) of 2.42 (NMRI-Hannover) and 2.12 (NMRI-Kisslegg). With combined open skin wound (SW) and irradiation in Hannover mice the following dose reduction factors were obtained: for irradiation and SW 10 min p.r. [post radiation] the DRF was 2.22, for irradiation and SW 2 day p.r. the DRF was 2.30 and for irradiation and SW 8 days p.r. the DRF was 2.29. In combined injuries with 2 burn wounds (BW) as the 2nd trauma in mice of the Kisslegg breed the DRF was 2.01 for irradiation and BW 10 min p.r. and the DRF was 1.91 for irradiation and BW 2 days p.r. The protective effect of WR 2721 is apparently similar in the groups with combined injuries compared to the animals exposed to only whole-body irradiation. The mechanisms of action of the S-containing radioprotective agents are discussed.