THE HERITABLE NATURE OF CLONAL CHARACTERISTICS IN ACUTE MYELOBLASTIC-LEUKEMIA
- 1 January 1981
- journal article
- research article
- Vol. 58 (1), 105-109
Abstract
Marked patient-to-patient variation is observed when blood or marrow from AML [acute myeloblastic leukemia] patients is examined using colony methods in culture. Concentrations of the progenitors of colonies change with time during the course of the disease. Blast cell self-renewal and drug sensitivity (adriamycin and cytosine arabinoside) were measured repeatedly in the courses of 7 AML patients. These properties were stable or slowly evolving. Capacity for renewal and sensitivities to certain chemotherapeutic drugs are heritable characteristics in leukemic clones.This publication has 7 references indexed in Scilit:
- Cytotoxicity of Adriamycin and Daunorubicin for Normal and Leukemia Progenitor Cells of Man2JNCI Journal of the National Cancer Institute, 1979
- SEPARATION OF BLAST CELL AND LYMPHOCYTE-T PROGENITORS IN THE BLOOD OF PATIENTS WITH ACUTE MYELOBLASTIC-LEUKEMIA1979
- SELF-RENEWAL IN CULTURE OF PROLIFERATIVE BLAST PROGENITOR CELLS IN ACUTE MYELOBLASTIC-LEUKEMIA1979
- Cytodifferentiation in the Acute Myeloblastic Leukemias of Man2JNCI Journal of the National Cancer Institute, 1978
- MARROW CULTURE STUDIES IN ADULT ACUTE-LEUKEMIA AT PRESENTATION AND DURING REMISSION1977
- SIMPLIFIED INVITRO CLASSIFICATION FOR PROGNOSIS IN ADULT ACUTE-LEUKEMIA - APPLICATION OF INVITRO RESULTS IN REMISSION-PREDICTIVE MODELS1976
- The distribution of colony‐forming cells among spleen coloniesJournal of Cellular and Comparative Physiology, 1963