Catalytic Enantioselective Amination of Enolsilanes Using C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids
- 23 July 1999
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 1 (4), 595-598
- https://doi.org/10.1021/ol990113r
Abstract
[Cu(S,S)-t-Bu-box](OTf)2 (1) catalyzes the enantioselective amination of enolsilanes with azodicarboxylate derivatives. Isomerically pure enolsilanes of aryl ketones, acylpyrroles, and thioesters added to the azo-imide in greater than 95% ee. The use of an alcohol additive was critical to achieving catalyst turnover.Keywords
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