Morphological and functional changes of pancreatic B cells in cyclosporin A-treated rats
- 1 September 1984
- journal article
- Published by Springer Nature in Diabetologia
- Vol. 27 (3), 416-418
- https://doi.org/10.1007/bf00304861
Abstract
Cyclosporin A (50 mg/kg orally for 7 days) produced severe degranulation and hydropic degeneration of islet B cells in rats. These changes were accompanied by hyperglycaemia and hypoinsulinaemia, while the pancreatic insulin content decreased by 75%.Keywords
This publication has 7 references indexed in Scilit:
- CYCLOSPORIN FOR PULMONARY SARCOIDOSISThe Lancet, 1984
- Effects of Cyclosporine Immunosuppression in Insulin-Dependent Diabetes Mellitus of Recent OnsetScience, 1984
- Clinical Aspects of Cyclosporine Therapy: A Summation1983
- DETERIORATION IN GLUCOSE METABOLISM IN PANCREATIC TRANSPLANT RECIPIENTS GIVEN CYCLOSPORINThe Lancet, 1983
- Toxicological evaluation of cyclosporin AArchives of Toxicology, 1983
- STUDIES ON THE IMMUNOSUPPRESSIVE PROPERTIES OF CYCLOSPORIN A IN RATS RECEIVING RENAL ALLOGRAFTSTransplantation, 1980
- Alpha Cell Cytotoxins: Their Influence on Carbohydrate Metabolism and the Effect of the Oral Blood Glucose Reducing Sulfonamides on the Islet CellsDiabetes, 1957