Chronic Papaverine Treatment: The Effect of Repeated Injections on the Simian Erectile Response and Penile Tissue

Abstract
To investigate the effect of chronic papaverine treatment, seven monkeys underwent repeated intracavernous injections for one year. One monkey died after 56 injections; the others received a total of 100 each. The strength and duration of erection were recorded after each injection, and the erectile tissue was examined histologically at the end of the study.