ANAEMIA OF CHRONIC DISEASE: DIAGNOSTIC SIGNIFICANCE OF ERYTHROCYTE AND SEROLOGICAL PARAMETERS IN IRON DEFICIENT RHUEMATIOD ARTHRITIS PATEINTS
- 1 April 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 29 (2), 105-110
- https://doi.org/10.1093/rheumatology/29.2.105
Abstract
Erythrocyte and serological parameters were assessed in 44 anaemic rheumatoid arthritis (RA) patients to detect irondeficiency as assessed by stainable bone marrow iron. The anaemia was normochromic normocytic in 60% and hypochromic normocytic in 30% of those with anaemia of chronic disease (ACD). Iron deficiency was present in 55%and the anaemia was hypochromic microcytic in 54% and hypochromic normocytic or normochromic normocytic in 21%. Iron absorption was found to be higher in iron deficient patients. In ACD patients, iron absorption correlated inversely with ESR and CRP. For the detection of iron deficiency among RA patients with ACD, the MCV showed the highest specificity (90%) and predictive value (87%). Serum ferritin was the most sensitive (82%) and valid (86%) test. Combination of MCV, ferritin and transferrin resulted in 100% validity. It was concluded that iron deficiency can be detected accurately without bone marrow aspiration using combinations of blood parameter.Keywords
This publication has 15 references indexed in Scilit:
- Serum erythropoietin in rheumatoid arthritis and other inflammatory arthritides: relationship to anaemia and the effect of anti‐inflammatory treatmentBritish Journal of Haematology, 1987
- Hematologic and Iron-Related Measurements in Rheumatoid ArthritisAmerican Journal of Clinical Pathology, 1987
- Aspirin and the StomachAnnals of Internal Medicine, 1986
- Red cell ferritin content: a re-evaluation of indices for iron deficiency in the anaemia of rheumatoid arthritis.BMJ, 1984
- Erythrocyte and plasma ferritin in normal subjects, blood donors and iron deficiency anemia patientsBlut: Zeitschrift für die Gesamte Blutforschung, 1984
- Serum Ferritin and the Assessment of Iron Deficiency in Rheumatoid ArthritisScandinavian Journal of Rheumatology, 1982
- A Method for the Investigation of Reticuloendothelial Iron Kinetics in ManBritish Journal of Haematology, 1979
- SERUM FERRITIN LEVELS IN ANEMIA OF RHEUMATOID-ARTHRITIS1977
- The diagnosis of iron deficiency anemiaAmerican Journal Of Medicine, 1964
- Comparison of Hemosiderin Estimation in Bone Marrow Sections and Bone Marrow SmearsActa Medica Scandinavica, 1964