Utilization and interconversions of purine derivatives in the fission yeastSchizosaccharomyces pombe

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Abstract
In the fission yeast Schizosaccharomyces pombe, growth responses of mutants strains in the de novo purine synthesis pathway, in the purine interconversion system, and of various double mutants, have been studied upon different purine-supplemented media. The results show that exogenous purine utilization as nucleotide source is based exclusively upon pyrophosphorylation of purine bases, and they make it possible to identify most of the enzymic steps acting, in this organism, upon a purine ring to give another purine ring.A scheme of the interconversion system in Schizosaccharomyces pombe is given.