Regulation of aversion to noxious food by Drosophila neuropeptide Y– and insulin-like systems
- 18 September 2005
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 8 (10), 1350-1355
- https://doi.org/10.1038/nn1540
Abstract
Omnivores, including humans, have an inborn tendency to avoid noxious or unfamiliar foods. Such defensive foraging behaviors are modifiable, however, in response to physiological needs. Here we describe a method for assessing risk-sensitive food acquisition in Drosophila melanogaster. Food-deprived fly larvae become more likely to feed on noxious foods (adulterated with quinine) as the duration of deprivation increases. The neuropeptide F receptor NPFR1, a mammalian neuropeptide Y (NPY) receptor homolog, centrally regulates the response to noxious food in D. melanogaster. Overexpression of NPFR1 was sufficient to cause nondeprived larvae to more readily take in noxious food, whereas loss of NPFR1 signaling led to the opposite phenotype. Moreover, NPFR1 neuronal activity may be directly regulated by the insulin-like signaling pathway. Upregulation of insulin-like receptor signaling in NPFR1 cells suppressed the feeding response to noxious food. Our results suggest that the coordinated activities of the conserved NPY- and insulin-like receptor signaling systems are essential for the dynamic regulation of noxious food intake according to the animal's energy state.Keywords
This publication has 42 references indexed in Scilit:
- Developmental Control of Foraging and Social Behavior by the Drosophila Neuropeptide Y-like SystemNeuron, 2003
- NPY ablation in C57BL/6 mice leads to mild obesity and to an impaired refeeding response to fastingAmerican Journal of Physiology-Endocrinology and Metabolism, 2003
- Recent advances in our understanding of risk-sensitive foraging preferencesProceedings Of The Nutrition Society, 2002
- Ablation of Insulin-Producing Neurons in Flies: Growth and Diabetic PhenotypesScience, 2002
- Neuropeptides and Neuropeptide Receptors in the Drosophila melanogaster GenomeGenome Research, 2001
- An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth controlCurrent Biology, 2001
- Behavioral characterization of neuropeptide Y knockout miceBrain Research, 2000
- Identification of a Drosophila brain-gut peptide related to the neuropeptide Y familyPeptides, 1999
- Neurobiology of Food and Fluid IntakePublished by Springer Nature ,1990
- Optimal foraging, the marginal value theoremTheoretical Population Biology, 1976