LOS ANGELES, CALIFORNIA-- As conventional silicon chips race toward their physical limits, researchers are seeking the Next Small Thing in electronics through chemistry. By making devices from small groups of molecules, researchers may be able to pack computer chips with billions of transistors, more than 30 times as many as current technology can achieve. This special focus section looks at new ways researchers are attempting to keep those gains coming, such as through extreme ultraviolet lithography (p. 785), and some hurdles they face in doing so (p. 787).