Clinical aspects of 100 patients with Kawasaki disease.
Open Access
- 1 February 1991
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 66 (2), 185-188
- https://doi.org/10.1136/adc.66.2.185
Abstract
We report 101 episodes of Kawasaki disease in 100 patients seen over a 12 year period. A total of 35 patients had cardiac involvement ranging from pericardial effusion to coronary artery aneurysms with ischaemic complications, which resulted in death in one patient. Laboratory investigations showed leucocytosis, thrombocytosis, and a raised erythrocyte sedimentation rate to be common features and the first two variables were significantly associated with cardiac involvement. Treatment regimens changed over the study period. Aspirin was used in most patients often in conjunction with dipyridamole and from 1986 intravenous immunoglobulin was given routinely to those patients seen early in the illness. Additional therapeutic measures in individual patients included prostacyclin, heparin, streptokinase, and plasma exchange/exchange transfusion. Attention is drawn to the uncertainity of the long term cardiovascular consequences in the light of adults reported with premature atherosclerotic lesions of similar appearance to those seen in Kawasaki disease.Keywords
This publication has 16 references indexed in Scilit:
- Kawasaki disease: echocardiographic features in 91 cases presenting in the United Kingdom.Archives of Disease in Childhood, 1990
- Antineutrophil cytoplasm antibodies in Kawasaki disease.Archives of Disease in Childhood, 1989
- Absence of significant RNA-dependent DNA polymerase activity in lymphocytes from patients with Kawasaki syndromeNature, 1989
- Coronary artery aneurysms and myocardial infarction: adult sequelae of Kawasaki disease?Heart, 1988
- Kawasaki SyndromeClinical Infectious Diseases, 1988
- Kawasaki syndromeThe Pediatric Infectious Disease Journal, 1987
- DOES KAWASAKI DISEASE HAVE A RETROVIRAL AETIOLOGY?The Lancet, 1986
- The Treatment of Kawasaki Syndrome with Intravenous Gamma GlobulinNew England Journal of Medicine, 1986
- Platelet immune complex interaction in pathogenesis of Kawasaki disease and childhood polyarteritis.BMJ, 1985
- Coronary artery aneurysms and Kawasaki's disease in an adult.Heart, 1984