Suppression of T‐lymphocyte cytotoxicity following exposure to sinusoidally amplitude‐modulated fields
- 1 January 1983
- journal article
- research article
- Published by Wiley in Bioelectromagnetics
- Vol. 4 (3), 281-292
- https://doi.org/10.1002/bem.2250040308
Abstract
Significant inhibition of allogeneic cytotoxicity of the target cell MPC-11 by the murine cytotoxic T-lymphocyte line CTLL-1 was observed when the 4-h cytotoxicity assay was conducted in the presence of a 450-MHz field sinusoidally amplitude-modulated at 60 Hz. Exposure of the effector cells to the field prior to adding them to the target cells in the cytolytic assay resulted in a similar inhibition, suggesting a direct interaction of the field with the cytolytic T lymphocyte. The inhibition was preferentially expressed during the early allogeneic recognition phase. Fieldexposed cytolytic cells recovered their full cytolytic capacity in 12.5 h. A differential susceptibility was observed with modulation frequencies from 0 to 100 Hz. Peak suppression occurred at 60 Hz modulation, with progressively smaller effects at 40, 16, and 3 Hz. The unmodulated carrier wave did not affect the cytotoxicity. Effects with 80- and 100-Hz modulation were smaller than at 60 Hz. These results demonstrate an inhibitory but recoverable effect by certain amplitude modulations of weak nonionizing radiation upon the cell-mediated cytolytic immune response.Keywords
This publication has 26 references indexed in Scilit:
- Alteration of circulating antibody response of mice exposed to 9‐GHz pulsed microwavesBioelectromagnetics, 1980
- Biologic effects of microwave exposure. II. Studies on the mechanisms controlling susceptibility to microwave‐induced increases in complement receptor‐positive spleen cellsBioelectromagnetics, 1980
- Induction of calcium‐ion efflux from brain tissue by radio‐frequency radiation: Effects of modulation frequency and field strengthRadio Science, 1979
- Immune response of mice to 2450‐MHz microwave radiation: Overview of immunology and empirical studies of lymphoid splenic cellsRadio Science, 1977
- Effects of radio‐frequency radiation on inflammationRadio Science, 1977
- THE EFFECT OF ELECTROMAGNETIC RADIATION ON THE HEMATOPOIETIC STEM CELLS OF MICEAnnals of the New York Academy of Sciences, 1975
- MICROWAVE EFFECTS ON THE BLOOD‐FORMING SYSTEM WITH PARTICULAR REFERENCE TO THE LYMPHOCYTEAnnals of the New York Academy of Sciences, 1975
- EFFECT OF 10-CM (3 GHz) ELECTROMAGNETIC RADIATION (MICROWAVES) ON GRANULOCYTES IN VITROAnnals of the New York Academy of Sciences, 1975
- SYNTHESIS, ASSEMBLY, AND SECRETION OF GAMMA GLOBULIN BY MOUSE MYELOMA CELLSThe Journal of Experimental Medicine, 1970