Construction of a Novel Oncogene Based on Synthetic Sequences Encoding Epidermal Growth Factor
- 16 January 1987
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 235 (4786), 321-324
- https://doi.org/10.1126/science.3492043
Abstract
The autocrine model postulates that constitutive release of a mitogenic growth factor can lead to uncontrolled proliferation and cell transformation. A synthetic polynucleotide encoding epidermal growth factor conferred a tumorigenic phenotype on cells. These cells were transformed through the action of an autocrine circuit having an extracellular component.This publication has 27 references indexed in Scilit:
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