Effect of New Adrenal Steroids on Electrolyte and Water Excretion

Abstract

Effects of prednisone, prednisolone, hydrocortisone and desoxycorticosterone on excretion of water, Na, and K, were compared in water-loaded adrenalectomized rats. All steroids stimulated water diuresis and K excretion. Hydrocortisone, prednisone and prednisolone were equi-potent; desoxycorticosterone was weaker. Hydrocortisone, prednisone and prednisolone stimulated Na excretion at all doses having any effect and were again approximately equi-potent. Desoxycorticosterone had the opposite effect and caused Na retention. The relative inability of the delta1-steroids to cause Na retention under conditions of clinical use is, therefore, not associated with any comparable inability to cause natriuresis under appropriate circumstances.