Trypsin-like Immunoreactivity as a Test for Pancreatic Insufficiency

Abstract

AT present, the clinician has several tests available for the assessment of pancreatic function. However, many of these tests lack sensitivity or specificity or both, or are difficult to perform. Recently, an enzymatic assay kit for trypsin-like immunoreactivity has been made available. This kit, called the Trypsik kit, assays for cathodic trypsinogen, a zymogen synthesized only by the pancreas. A depressed serum level of trypsin-like immunoreactivity has been reported in patients with alcohol-induced chronic pancreatitis¹ and cystic fibrosis.² The objectives of this study were to evaluate the sensitivity and specificity of a decreased serum level of trypsin-like immunoreactivity as a . . .